Medical Products Laboratories, Inc. (MPL) is a full-service pharmaceutical contract manufacturer and packager specializing in liquid pharmaceutical contract manufacturing. MPL plays an integral role in product realization, from lab scale-up, to pilot batch and commercial production. MPL's liquid pharmaceutical manufacturing capabilities range from topical and oral liquids to syrups and suspensions. No customer is too large or too small. MPL can tailor its batch sizes to meet each of its customers' specific needs.
All of MPL's pilot and full-scale mixing systems are designed to replicate the laboratory requirement to ensure successful scale-up from R&D lab batches to commercial-size manufacturing. MPL's in-house purchasing team sources each raw material to perform a specific function in all liquid formulations. MPL's Quality Control team tests all raw materials in accordance to approved specifications prior to release for use in liquid contract manufacturing.
A work order is generated by MPL's product support team upon receipt of a customer order, and raw materials are staged for weighing. HEPA filtration and positive pressure are used to prevent cross contamination in the weighing suites, and each material is weighed separately, one at a time, with cleaning procedures performed between each measurement to prevent cross contamination or mix up. Regular calibration of all balances are performed to ensure accuracy. To ensure purity of the most commonly used raw material, USP-grade purified water is produced by our dual de-ionized water systems, which are monitored daily for total organic carbon, ensuring purity of the most common raw material. Raw materials are traced with MPL's enterprise resource planning (ERP) system. MPL's process ensures the highest level of quality achieved during the manufacturing process of all products, including liquid formulations.
Batch sizes for liquid contract manufacturing range from 30 to 3,000 gallons. Liquid formulations are mixed using overhead Lightnin mixers with VFDs capable of low speeds to over 5,000 RPM. MPL also has high sheer mixing capability for liquid products which are more difficult to get into solution. MPL's GMP manufacturing suites are designed for specific mixing systems, and use FDA-approved washable walls, shatter-proof lighting fixtures, and separate air handling systems, making them ready for virtually any raw material blend. HEPA filtration and pressurization, dedicated hazard areas, and an extensive environmental monitoring program ensure zero cross contamination.
MPL's GMP manufacturing suites are constructed from FDA-approved washable walls, shatter-proof lighting fixtures, powder extraction arms, and separate air handling systems, and can handle virtually any raw material blend. HEPA filtration and pressurization, along with dedicated hazard areas and an extensive environmental monitoring program, eliminate cross contamination. The staff is dedicated to following the latest version of the approved batch record, with each step in the manufacturing process performed and witnessed for double verification. The Quality Control lab is on site for quick reporting of results to any in-process testing that may be necessary so formulation adjustments can be made as quickly as possible. Process validations are generally performed on the first three lots produced, and then again according to the company's periodic validation schedule. Once the batch is completed, it is stored in a transfer tank until the packaging process is ready to commence.
MPL provides liquid contract manufacturing of the highest standards. The focus on efficiency in the manufacturing process allows MPL to offer some of the highest values among contract manufacturers of pharmaceutical, human, and veterinary liquid formulations. Submit a New Product Request Form today and see how MPL can deliver for you.